Full resolution (JPEG) - On this page / på denna sida - Contributions to the Biology and Morphology of Spiroptera (Gongylonema) Neoplastica n. sp.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
ficially infected cockroaches (P. orientalis) 7 rats presented tumour growths, 6 definite hyper-
trophy of tlie epithelium, while 3 rats did not show any pathological changes — besides ne-
matodes.
In the slightly definite cases (16 rats) the cardiac portion of the stomach. was only changed
very moderately, tlie hypertrophy of the mueous membrane being either circumscribed or diffuse.
Corresponding to this, the microscopical examination showed a proliferation of the squamous-
celled epithelium of the mueous membrane, combined with a definite hypertrophy and desqua-
mation of the stratum corneum. As a rule, the mueous membrane and submucosa contained
slight inflammatory processes consisting mainly in colonies of leucocytes, lymphocytes and
plasma-cells.
In cases where the pathological changes must be characterized as definite (29 rats) the
condition of the mueous membrane was diffusely hypertrophic, irregularly folded and wrinkled,
often beset with small papillomatous prominences. In microscopical examination the mueous
membrane, and the connective tissue of submucosa appeared to be proliferated, the latter
forming the stock of small papillomes which protruded on the surface of the mueous membrane
and were covered with hyperplastic epithelium; in some cases the inflammation had even
reached the muscularis and the serosa.
The proliferation of the epithelium was very definite, not only was the stratum corneum
hypertrophically changed but the lower coats as well; and often long tongues of epithehum
were seen going deep down, displacing, and even perforating the muscularis mucosæ, so that
submucosa contained spurs of epithelial islets.
In cases where the pathological changes showed themselves as violent or as tumour growths
(23 rats in all) the stomach was very much enlarged, the wall of the cardiac portion very
thick, and the mueous membrane set with petiolate irregularly branched papillomes or wall-
like prominences, which in all cases made the ventral wall measure nearly 1 — 1^3 mm. in
sections; in several cases the cavity of the fundus was absolutely diminished by the papil-
lomes, which in other cases not only caused an obliteration of the cavity but even pro-
truded into the pyloric portion. The outside of the stomach was irregularly rugged, with
globular or flat prominences; in some cases even petiolate protuberances were observed.
Microscopical examination showed that these changes were due to a further development
of the tumours already described.
The connective tissue of the submucosa appeared to be a seat of violent inflammatory
processes and new growth, so that branched coral- or crater-shaped prominences of connective
tissue covered with coats of hyperplastic epithelium, projected into the stomach as enormous
papillomes, 1 — IV2 cm. high.
By cooperation of these various processes:
Proliferation of the heterotopic epithehum, and inflammation and new growth of the
connective tissue of submucosa, enormous pathological changes were produced. In faet, the
prohferation of the heterotopic epithehum in several cases destroyed the papillomatous wall
of the fundus to such an extent that it consisted of nothing but great masses of epithelium
covered with a thin serosa. In such cases the bundles of muscularis were atrophic, dismembered
or quite destroyed. In all cases a definite eosinophily was observed in mucosa and submucosa
of the ventral wall.
Moreover, it must be pointed out that in 5 laboratory rats fed on cockroaches (in 4 cases
<< prev. page << föreg. sida << >> nästa sida >> next page >>
