Full resolution (JPEG) - On this page / på denna sida - V. The Blood - I. Blood-plasma and Blood-serum - The Blood-plasma
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
FIBRINOGEN. 253
without any changes in the bone-marrow speak against the especially
great importance of the spleen and bone-marrow for the formation of
fibrinogen. That the liver takes part in the formation of fibrinogen
is implied by the fact that the quantity of fibrinogen in the blood
strongly diminishes after the extirpation of the liver (Nolf), and that
fibrinogen may indeed be entirely absent in the blood in phosphorus
poisoning (Corin and Ansiaux, Jacoby, Doyon, Morel, and Kareff l
),
and that the blood of the hepatic vein, according to Doyon, Morel
and Kareff, is richer in fibrinogen than the blood from other vessels,
and finally according to Whipple and Hurwitz 2 in chloroform poison-
ing the fibrinogen content of the blood diminishes with the injury to
the liver and rises again with restitution of the organ.
Fibrinogen has the general properties of the globulins, but differs
from other globulins as follows: In a moist condition it forms white
flakes which are soluble in dilute common salt solutions, and which
easily conglomerate into tough, elastic masses or lumps. The solution
in 5-10 per cent NaCl coagulates on heating at 52-55° C, and the faintly
alkaline or nearly neutral weak salt solution coagulates at 56° C, or at
exactly the same temperature at which the blood-plasma coagulates.
Fibrinogen solutions are precipitated by an equal volume of a saturated
common salt solution, and are completely precipitated by adding an excess
of NaCl in substance (thus differing from serglobulin) . A salt-free
solution of fibrinogen in as little alkali as possible gives with CaCb
a precipitate which contains calcium and soon becomes insoluble. In
the presence of NaCl or by the addition of an excess of CaCk the precipitate
does not appear.3
A neutral solution of fibrinogen is precipitated by
a concentrated solution of sodium fluoride when added in a sufficient quan-
tity. Fibrinogens from different kinds of blood behave somewhat dif-
ferently in this regard. According to Huiskamp 4
fibrinogen from horse-
blood hardly dissolves in NaCl of 3-5 per cent at ordinary temperatures,
while it does dissolve at 40-45°. It also dissolves in ammonia of 0.05
1
P. Miiller, Hofmeister’s Beitrage, 6; Mathews, Amer. Journ. of Physiol., 3; Nolf,
Bull. Acad., Roy. Belg., 1905, and Arch, intern, de Physiol., 3, 1905; Langstein, and
Mayer, Hofmeister’s Beitrage, 5; Morawitz and Rehn, Arch. f. exp. Path. u. Pharm.,
58; Corin and Ansiaux, Mary’s Jahresber., 24; Jacoby, Zeitschr. f. physiol. Chem.,
30; Doyon, Morel and Kareff, Compt. Rend., 140; Do3’on, Morel, and P6ju, Comp.
rend. soc. biolog., 58; Doyon, CI. Gautier, and Morel ibid., 62; Doyon, Gautier
and Mawas, ibid., 64.
2
Doyon, Morel and Kareff, Journ. de Physiol., 8 (1906); Whipple and Hurwitz,
Journ. of exp. Med. 13. See also Meek, Amer. Journ. of Physiol., 30.
3
See Hammarsten, Zeitschr. f. physiol. Chem., 22; Cramer, ibid., 23.
4 Huiskamp, ibid., 44 and 46. In regard to fibrinogen the reader is referred to
the author’s investigations. Pfluger’s Archiv., 19 and 22, and Zeitschr. f. physiol.
Chem., 28.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
