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29S THE BLOOD.
ing oxime of methylethylmaleic imide. The third pyrrol found by
Willstatter, which he calls phyllopyrrol, is a tetra-substituted pyrrol,
H3 C.C C.C2H5
namelv, 2, 3, 5 trimethyl-4-ethvlpyrrol =
H3C.C—NH—C.CH3
The statement that the haemopyrrol of Willstatter is in part derived
from cryptopyrrol is not correct, and must be changed because of the
investigations of Piloty and Stock, who find that the haemopyrrol of
Willstatter (and Asahina) undoubtedly contains cryptopyrrol, but
consists chiefly of the B-haemopyrrol, consequently isohaemopyrrol. Ac-
cording to more recent investigations of Piloty and Stock l
the haemo-
pyrrol question is even more complicated than was expected.
In the crude pyrrol obtained by the reduction of the blood pigments
several other pyrrol bodies have been found, for example the phonopyrrol
of Piloty which has not been sufficiently explained. According to
Grabowski and Marchlewski 2
as well as to Piloty and Stock, the
crude haemopyrrol contains also disubstituted pyrrol, namely, jSi, /3-methyl-
ethylpyrrol. On fusing haematoporphyrin or haematopyrrolidinic acid
(see below) with caustic alkali we obtain, according to Piloty, a mixture
of pyrrols among which we will mention 2, 3-dimethylpyrrol
HC- C.CH3
,
which has been studied by Piloty and Wilke.3
HC—NH—C.CH3
By the reduction of haematoporphyrin and haemin by various methods,
Piloty and co-workers have obtained, besides haemopyrrol, several
acids namely haematopyrrolidinic acid, phonopyrrolcarboxylic acid
(isophonopyrrolcarboxylic acid) and xanthopyrrolcarboxylic acid. The
haematopyrrolidinic acid seems from the most recent investigations
not to be a unit substance. Piloty obtained from it phonopyrrolcar-
H3C.C C.CH2 .CH2 .COOH
boxylic acid, C9 Hi3N02
= which on
H3C.C—NH—CH
treatment with nitrous acid lost a methyl group and was converted into
H3 C.C CCH2CH2.COOH.
the oxime of haematinic acid, The acid
HONC—NH—CO
received this name because, according to Piloty, it yields a special
dimethylethylpyrrol, called phonopyrrol by him. The question as to the
nature of xanthopyrrolcarboxylic acid and its occurrence has not been
1
Piloty and Stock, Annal. d. Chem. u. Pharm., 392 and Ber. d. d. chem. Gesellsch.,
46, 1008.
’-’
Grabowski and Marchlewski, Zeitschr. f. physiol. Chem., 81.
’ Piloty and Wilke, Ber. d. d. chem. Gesellsch., 45.
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