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36S CHYLE, LYMPH, TRANSUDATES AND EXUDATES.
nucleate. We cannot say whether this applies to the two nucleohistones
(if there are two). The nucleohistone or mixture of nucleohistones
behave like an acid, whose salts, especially the calcium salt, have been
closely studied by Huiskamp. On the electrolysis of a solution of alkali
nucleohistone in water Huiskamp also found that the nucleohistone
collected in traces at the anode, and that the sodium compound is there-
fore ionized in the solution. The nucleic acid-calcium histone-com-
pound has been prepared, it seems, in a pure state by Bang, and he found
the following average composition: C 43.69; H 5.60; N 16.87; S 0.47;
P 5.23; Ca 1.71 per cent.
The nucleohistone prepared by Huiskamp’ s method of precipitating with
CaCb is, according to him, a mixture of two nucleohistones, of which one, the
a-nucleohistone, contains 4.5 per cent phosphorus, and the other, |3-nucleohistone
contains, on the contrary, only in round numbers 3 per cent phosphorus. 1
As
the two nucleohistones are poorer in phosphorus than the nucleic acid-histone
compound analyzed by Bang, and as Huiskamp on cleavage of his preparation
did not, like Bang and Malengreau, obtain pure nucleic acid, it is still a ques-
tion whether Huiskamp was working with sufficiently pure substances.
In regard to the methods used by the above investigators in the
isolation of the bodies in question we must refer to the original publications.
In connection with the so-called nucleohistone, attention must be called to
tissue fibrinogen and cell fibrinogen, which are compound proteins, and are claimed
by certain investigators to stand in close relation to the coagulation of the blood.
These may be in part nucleoproteins and in part also nucleohistones. To this same
group belong also the important cell constituents described by Alex. Schmidt 2
and called cytoglobin and preglobulin. The cytoglobin, which is soluble in water,
may be considered as the alkali compound of preglobulin. The residue of the
cells left after complete extraction with alcohol, water, and salt solution has
been called cytin by Alex. Schmidt.
Besides the above-mentioned and the ordinary bodies belonging to
the connective-tissue group, small quantities of fat, leucine, succinic
acid, lactic acid, sugar, and traces of iodothyrin are present. According
to Gautier 3
arsenic also occurs in very small amounts, and no doubt
here as well as in other organs it is related to the nuclein substances. The
richness in nuclein bodies explains the occurrence of large quantities
of purine bases, chiefly adenine, whose quantity, according to Kossel
and Sciiindler,4
is 1.79 p. m. in the fresh organ and 19.19 p. m. in the
dry substance, and guanine. The bodies thymine and (uracil?) obtained,
besides lysine and ammonia, by Kutscher, as products of autodiges-
tion of the gland, probably have a similar origin. Among the enzymes,
1
Zeitschr. f. phy.siol. Chem., 39.
2
See footnote 1, p. 307.
8
Compt. Rend., 129.
* Zeitschr. f. physiol. Chem., 13; Kutacher, Zeitachr. f. phyaiol. Chem., 34.
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