Full resolution (JPEG) - On this page / på denna sida - VII. The Liver - The Bile and its Formation
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
BILE SECRETION. 415
In starvation the secretion diminishes. According to Lukjanow
and Albertoni, 1
under these conditions the absolute quantity of solids
decreases, while the relative quantity increases. After partaking of
food the secretion increases again. The findings are very contradictory
in regard to the time necessary, after partaking of food, before the
secretion reaches its maximum. After a careful examination and com-
pilation of all the existing reports, Heidenhain 2
has come to the con-
clusion that in dogs the curve of rapidity of secretion shows two maxima,
the first at the third to fifth hour and the second at the thirteenth to
fifteenth hour after partaking of food. According to Barbera the
time when the maximum occurs is dependent upon the kind of food.
With carbohydrate food it is two to three hours, after protein food three
to four hours, and with fat diet it is five to seven hours, after feeding.
According to Loeb3
the maximum occurs in dogs one to two hours after
feeding with meat, casein or gliadin.
According to earlier observations, the proteins of all the various
foods cause the greatest secretion of bile, while the carbohydrates dimin-
ish the secretion, or at least excite it much less than the proteins. This
coincides with the recent observations of Barbera. The authorities
by no means agree as to the action of the fats. While many older
investigators have not observed any increase, but rather the reverse
in the secretion of bile after feeding with fats, the researches of Barbera
show an undoubted increase in the secretion of bile on fat feeding, greater
even than after carbohydrate feeding. According to Rosenberg olive-
oil is a strong cholagogue, a statement which, according to other inves-
tigators
—
Mandelstamm, Doyon and Dufourt ’
—has not been proved.
As Barbera has shown, a close relation exists between the bile
secretion and the quantity cf urea formed, as an increase in the first
goes hand in hand with an increase of the latter. The bile is, therefore,
according to him, a product of disassimilation, whose quantity rises and
falls with the degree of activity of the liver.
The question whether there exists special medicinal bodies, so-called
cholagogues, which have a specific excitant action on the secretion of
lukjanow, Zeitschr. f. physiol. Chem., 16; Albertoni, Recherches sur la s£cr6tion
biliaire, Turin, 1893.
2
Hermann’s Handb., 5, and Stadelmann, Der Icterus, etc.
3
Barbera, Centralbl. f. Physiol., 12 and 16; A. Loeb, Zeitschr. f. Biol., 55.
4
Barbera, Bull, della scienz. med. di Bologna (7), 5, Maly’s Jahresber., 24, and
Centralbl. f. Physiol., 12 and 16; Rosenberg, Pfluger’s Arch., 46; Mandelstamm. Ueber
den Einfluss einiger Arzneimittel auf Sekretion und Zusammensetzung der Galle (Dis-
sert. Dorpat, 1890); Doyon and Dufourt, Arch, de Physiol, (o), 9. In regard to the
action of various foods on the secretion of bile see also Heidenhain, 1. c; Stadelmann,
Der Icterus; and Barbera, 1. c.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
