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556 TISSUES OF THE CONNECTIVE SUBSTANCE.
Erwin Voit, Aron and Sebatjer and others x
produced, by lack of
lime-salts, a change similar to rachitis. In full-grown animals the
bones were changed after a long time because of the lack of lime-salts
in the food, but did not become soft, only thinner (osteoporosis). The
attempts to remove the lime-salts from the bones by the addition of
lactic acid to the food have led to no positive results (Heitzmann,
Heiss, Baginsky 2
). Weiske, on the contrary, has shown, by admin-
istering dilute sulphuric acid or monosodium phosphate with the food
(presupposing that the food gave no alkaline ash) to sheep and rab-
bits, that the quantity of mineral bodies in the bones might be dimin-
ished. On feeding continuously for a long time with a food which yielded
an acid ash (cereal grains), Weiske observed a diminution in the min-
eral substances of the bones in full-grown herbivora.3
A few investi-
gators are of the opinion that in rachitis, as in osteomalacia, in which
disease the calcium content of the bones is also diminished, a solution
of the lime-salts by means of lactic acid takes place. This was sug-
gested by the fact that O. Weber and C. Schmidt 4
found lactic acid,
in the cyst-like, altered bony substance in osteomalacia.
Well-known investigators have disputed the possibility of the lime-
salts being washed from the bones in osteomalacia by means of lactic
acid. They have given special prominence to the fact that the lime-
salts held in solution by the lactic acid must be deposited on neutraliza-
tion of the acid by the alkaline blood. This objection is not very impor-
tant, as the alkaline blood-serum has the property to a high degree of
holding earthy phosphates in solution, which fact has been recently
shown by Hofmeister. The investigations of Levy contradict the
claim as to the solution of the lime-salts by lactic acid in osteomalacia.
He found that the normal relation 6PC>4:10Ca is retained in all parts
of the bones in osteomalacia, which would not be the case if the bone-
earths were dissolved by an acid. The decrease in phosphate occurs in
the same quantitative relation as the carbonate, and according to Levy,
in osteomalacia the exhaustion of the bone takes place by a decalcifica-
tion in which one molecule of phosphate-carbonate after the other is
removed. This does not agree with the findings of MoCrudden 5 who
1
Zeitschr. f. Biologie, 16; Aron and Sebauer, Bioch. Zeitsohr., 8; A. Baginsky,
Arch. f. (Anat. u.) Physiol., 1881.
2
Heitzmann, Maly’s Jahresber., 3, 229; Heiss, Zeitschr. f. Biolojrie, 12; Basrinsky;,
Virchow’s Arch., 87.
3
See Maly’s Jahresber., 22; also Weiske, Zeitschr. f. physiol. Chem., 20, and
Zeitschr. f. Biologie, 31.
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