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DROCHROME. 741
alcohol (v. Udraxszky ’)• To these humin bodies developed by the action of
acid in norma] urine when exposed bo tin- air must be added the urophain of Heller,
the various uromelanins and other bodies described by different investigators
(Pl6bz, ThUDICHUM, BchunCK, DombbOWBKI *). Indigo blue (uroglaucin of
Heller, vrocyanin, cyanurin, and other coloring matters of earlier investigators 3
)
is split off from the indoxyl-sulphuric acid or indoxyl-glucuronic acid. Red
coloring matter may be formed from the conjugated indoxyl and skatoxyl acids,
and urohodin (Heller), urorutrin (Plosz), urohcemabin (Harley), and perhaps
also uroroscin (Nencki and Sieber 4
) probably have such an origin.
We cannot discuss more in detail the different coloring matters obtained
as decomposition products from normal urine. Haematoporphyrin has
already been referred to in a previous chapter (V) and will best be
described in connection with the pathological pigments. It only remains
to describe urochrome, urobilin, and uroerythrin.
Urochrome is the name given by Garrod to the yellow pigment of
the urine. Thudichum 5
had previously given the same name to a less
pure pigment isolated by himself. The accounts as to the composi-
tion and properties of urochrome differ so considerably that it is ques-
tionable whether anybody has ever had this pigment in a pure form.
Urochrome is free from iron, but contains nitrogen. Dombrowski
found 11.15 per cent nitrogen, Hohlweg found 9.89 per cent nitrogen,
and Klemperer found only 4.2 per cent nitrogen. According to
Dombrowski urochrome contains about 5 per cent sulphur, while
other investigators like Hohlweg, Salomonsen, and Mancini found
that it was free from’ sulphur.6 According to Garrod it stands in
close relation to urobilin and is transformed into urobilin by the action
of " active " acetaldehyde, while Riva 7 claims to have obtained a body
similar to urochrome by the oxidation of urobilin by permanganate.
This relation of the two pigments is denied by Dombrowski. On the
contrary it is the unanimous opinion that urochrome under certain con-
ditions may yield the pyrrol reaction. Certain investigators such as
Bondzynski and Dombrowski consider urochrome as a member of the
oxyproteic acid group (see further on), a view which does not seem to
1
v. Udranszky, Zeitschr. f. physiol. Chem., 11, 12, and 13.
* P16sz, Zeitschr. f. physiol. Chem., 8; Thudichum, Brit. Med. Journ., 201, and
Journ. f. prakt. Chem., 104; Schunck, cited from Huppert-Neubauer, 10. Aufl., 509;
Dombrowski, Zeitschr. f. physiol. Chem., 62.
s
See Huppert-Neubauer, 161.
* In regard to this and other red pigments, see Huppert-Neubauer, 593 and 597;
Nencki and Sieber, Journ. f. prakt. Chem. (2). 26.
6
Garrod, Proc. Roy. Soc, 55; Thudichum, 1 c.
•Dombrowski, Zeitschr. f. physiol. Chem., 54 and 62; Hohlweg, Bioch. Zeitschr.,
13; Salomonsen. ibid., 13; Mancini, ibid., 13; Klemperer, Berl. klin. Wochenschr.,
40.
T
Garrod, Journ. of Physiol., 21 and 29; Riva, cited from Huppert-Neubauer, 524.
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