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METABOLISM WITH A MIXED DIET. 913
admitted, the amino-acids can serve in the building up of the proteins,
then there is no use denying that their amides can also be used by the
animal body.
Recently Grafe, Abderhalden l
and their collaborators have carried
on investigations on the value of ammonia and of urea as protein sparers
and protein formers. These investigations have shown that ammonia
or urea under special conditions of experimentation may cause a nitrogen
retention, but we are not justified in believing that a synthesis of protein
from ammonia takes place.
Metabolism on a Diet Consisting of Protein, with Fat or Carbohydrates.
As the various foodstuffs can replace each other as sources of energy in
the food it follows that the non-nitrogenous foodstuffs can be used
instead of the proteins and can reduce the catabolism of these. Thus
the fat cannot completely arrest or prevent the catabolism of proteins,
but it can decrease it and so spare the proteins. This is apparent from
the following table by Voit.2
A is the average for three days, and B
for six days.
Food. Flesh.
A
B
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