Full resolution (JPEG) - On this page / på denna sida - VIII. Digestion - VI. Absorption
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
536 DIGESTION.
fats occurs in the intestinal canal, and also as the fatty acids do not
occur in the chyle as such, but as emulsified fat after a synthesis with
glycerin into neutral fats, it is to be doubted whether the emulsified
fat of the chyle originates from an absorption of emulsified fat in the
intestine or from a subsequent emulsification of neutral fats formed
synthetically. This doubt has greater warrant in the observation of
Frank l
that the fatty-acid ethyl ester is extensively taken up from the
intestine, not as such, but as split-off fatty acids from which then the
neutral emulsified fats of the chyle are formed.
The assumption of an absorption of fats as an emulsion is inconsist-
ent with the fact that an emulsion produced by means of soaps is not
permanent in an acid liquid; hence we cannot consider as possible the
presence of an emulsion in the intestine so long as it is acid. This
difficulty is not too serious, as the reaction is often only due to carbonic
acid and bicarbonates, and besides as found by Kuhne and recently
shown by Moore and Krumbholz,2
the proteins have a preserving
action upon fat emulsions.
The earlier opinions as to fat absorption were, that fat was absorbed
as soaps, soluble in water, as well as finely emulsified fat, and this last
form was considered as of the greatest importance. This view has
recently undergone essential modifications, due to the work of Moore
and Rockwood, and especially to the extensive work of Pfluger.3
Moore and Rockwood have shown the great solvent action of the
bile for fatty acids, and on continuing these investigations further,
Moore and Parker have found that the bile increases the solubility
of soaps in water, and can prevent their gelatinization, a fact which is
of greater importance for the absorption of fats than the solubility of
the fatty acids in bile. The quantity of lecithin in the bile is of great
importance for the solubility therein of the fatty acids as well as the
soaps. According to the above-mentioned investigators, the absorption
of fat from the intestine is essentially dependent upon the solubility of
the soaps and free fatty acids in the bile. The neutral fats are split
and the free fatty acids are in part absorbed, dissolved as such by the
bile, and in part combined with alkalies, forming soaps. Neutral fats
are regenerated from the fatty acids, and the alkali set free from the
soaps is secreted again into the intestine and used for the re-formation
1
Zeitschr. f. Biologie, 36.
1
Kuhne, Lehr. der physiol. Chem., 122; Moore and Krumbholz, Journ. of Physiol.,
22.
3
In regard to the recent literature on fat absorption, see the works of Pfluger,
Pfluger’s Arch., 80, 81, 82, 85, 88, 89, and 90, where the work of other investigators is
cited and discussed. See also Croner, Bioch. Zeitschr. 23; Lombroso, Arch, di Fisiql. 5.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
