- Project Runeberg -  A text-book of physiological chemistry /
344

(1914) [MARC] Author: Olof Hammarsten Translator: John Alfred Mandel With: Gustaf Hedin - Tema: Chemistry
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344 THE BLOOD.
Muller, Ponfick). According to Worm Muller the normal quantity
of blood may indeed be increased as much as 83 per cent without pro-
ducing any abnormal conditions or lasting high blood-pressure. An
increase of 150 per cent in the quantity of blood may, with a considerable
variation in the blood-pressure, be directly dangerous to life (Worm
Muller). If the quantity of blood of an animal is increased by trans-
fusion with blood of the same kind of animal, an abundant formation
of lymph takes place. The water in excess is eliminated by the urine;
and as the protein of the blood-serum is quickly decomposed, while the
red blood-corpuscles are destroyed much more slowly (Tschirjew, Fors-
ter, Panum, Worm Muller 1
), a polycythemia is gradually produced.
The quantity of blood in the different organs depends essentially on
their activity. During work the exchange of material in an organ is
more pronounced than during rest, and the increased metabolism is
connected with a more abundant flow of blood. Although the total
quantity of blood in the body remains constant, the distribution of the
blood in the various organs may be different at different times. As a
rule the quantity of blood in an organ is an approximate measure of the
more or less active metabolism going on in it, and from this point of
view the distribution of the blood in the different organs is of interest.
According to Ranke,2
to whom we are especially indebted for our knowl-
edge of the relation of the activity of the organs to the quantity of blood
contained therein, of the total quantity of blood (in the rabbit) about
one-fourth comes to the muscles in rest, one-fourth to the heart and the
large blood-vessels, one-fourth to the liver, and one-fourth to the other
organs.
1
Panum, Xord. med. Ark., 7; Virchow’s Arch., 63; Landois, Centralbl. f. d.
med. Wissensch., 1875, and Die Transfusion des Blutes, Leipzig, 1875; Worm Muller,
Transfusion und Plethora; Ponfick, Virchow’s Arch., 62; Tschirjew, Arbeiten aus
der physiol. Anstalt zu Leipzig, 1874, 292; Forster, Zeitschr. f. Biologie, 11; Panum,
Virchow’s Arch., 29.
2
Die Blutvertheilung und der Thatigkeitswechsel des Organe, Leipzig, 1871.

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