Full resolution (JPEG) - On this page / på denna sida - VI. Chyle, Lymph, Transudates and Exudates - Appendix. Lymphatic Glands, Spleen and Endocrinic Glands
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
THYROID GLAND. 373
formation of uric acid. This relation has been studied by Horbac-
zewski. He has shown that when the spleen-pulp and blood of calves
arc allowed to act on each other, under certain conditions and certain tem-
perature, in the presence of air, large quantities of uric acid are formed,
and he has also shown that the uric acid originates from the nucleins of
the spleen. 1
This behavior is explained by the above-mentioned inves-
tigations of Burian, Schittenhelm, Jones, and others on the enzymotic
formation of uric acid, and the deamidization of the purine bodies, and a
relation between the spleen and uric-acid formation is indisputable.
Still we cannot say that the spleen shows a special relation to the uric-acid
formation as compared with other organs (see Chapter XIV).
The spleen has the same property as the liver of retaining foreign
bodies, metals and metalloids.
The Thyroid Gland. The nature of the different protein substances
occurring in the thyroid gland has not been sufficiently studied, but at
present, through the researches of Oswald, there are known at least two
bodies which are constituents of the so-called secretion of the glands,
the colloids. One of these, iodothyreoglobulin, behaves like a globulin, while
the other is a nucleoprotein (see also Gotjrlay 2
). The iodine present
in the gland occurs chiefly in the first body, while the arsenic, which has
been shown to be a normal constituent by Gautier and Bertrand,*
seems to be related to the nuclein substances.
According to Oswald the iodothyreoglobulin occurs only in those
glands which contain colloid, while the colloid-free glands, the parenchyma-
tous goitre, and the glands of the new-born contain thyreoglobulin free
from iodine. The thyreoglobulin first becomes iodized into iodothyreo-
globulin on passing from the follicle-cells. Besides these mentioned
bodies leucine, xanthine, hypoxanthine, choline, iodothyrine, lactic and
succinic acids occur in the thyreoidea. Like certain other organs, sub-
stances also occur in the thyroid which act upon the blood pressure and
indeed partly as vasodilator and partly depressing but whose chemical
nature has not been positively established. Among the enzymes we
•find lipases and catalases which, according to Juschtschenko,4
are
related to the corresponding enzymes of the blood. Magnus-Levy 5
found 757 parts water, 243 parts solids, 43.8 parts fat, 26.8 parts nitrogen,
and 0.058 parts iron in 1000 parts of the human thyroid gland.
1
Monatshefte f. Chem., 10, and Wein. Sitzungsber. Math. Nat. Klasse, 100, Abt. 3.
2
Gourlay, Journ. of Physiol., 16; Oswald, Zeitschr. f. physiol. Chem., 32, and
Biochem. Centralbl., 1, 249.
3
Gautier, Compt. Rend., 129. See also ibid., 130, 131, 134, 135; Bertrand, ibid.,
134, 135.
4
Juschtschenko, Bioch. Zeitschr., 25 and Arch, scienc. biol. de St. Petersbourg, 15.
5
Bioch. Zeitschr., 24.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
