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PROTEIN FATTENING. 919
after 32 days nitrogenous equilibrium had not occurred. On feeding
with 1800 grams of meat and 250 grams of fat nitrogen us equilibrium
was established ;ifter seven days; and though the deposition of flesh
per day was greater, still the absolute deposit was not one-half as great
as in the former case.
The possibility of a protein fattening in man and animals (dogs, sheep)
is shown by the series of experiments of Krug, Bornstein, Schreuer,
Henneberg, Pfeiffer and Kalb and others 1
and there is no doubt
that such a fattening is possible. That we are here not dealing with an
increase in the number of cells, but rather an enlargement of the volume
of the same is the generally accepted view. Theories as to the value and
nature of this protein-fattening are still divergent, as we must differentiate
between flesh accumulation or actual organ formation and protein
accumulation or deposition of dead protein, and opinions vary in
regard to the question how far the one or the other of these occur.
By determining the relation between P2O5 and N in muscles, kidneys
and liver in dogs and hens in starvation and in fattening, Grund 2
has
tested this possibility experimentally. If we are dealing with the deposi-
tion of dead protein then the relationship of the P2O5 to the N would
change in favor of the nitrogen; Grund found only a very slight change
of this kind, which was not conclusive, and according to him the various
organs have correspondingly a certain tendency of maintaining the rela-
tion between phosphorus and nitrogen unchanged in starvation as well
as in fattening.
It is difficult to produce a permanent flesh deposit in adult man by
overfeeding alone. It is to a much greater degree a function of the specific
growth energy of the cells and the cell-work than the excess of food.
Therefore there is observed, according to v. Noorden, abundant flesh
deposition (1) in each growing body; (2) in those no longer growing, but
whose body is accustomed to increased work; (3) whenever, by previous
insufficient food or by disease, the flesh condition of the body has been
diminished and therefore requires abundant food to replace it. The
deposition of flesh is in this case an expression of the regenerative energy
of the cells.
3 > *< T-/.I> ’
The experiences of graziers show that in food-animals a flesh deposit
does not occur, or at least is only inconsiderable, on overfeeding. The
1
Krug, Cited by v. Noorden, Lehrb. der Path, des Stoffwechsel, 1. Aufl., p. 120;
Bornstein, Berl. klin. Woehenschr., 1898, and Pfluger’s Arch., 83 and 106; Bornstein
and Schreuer, Pfliiger’s Arch., 110; Henneberg and Pfeiffer, see Maly’s Jahresb.,
20; Pfeiffer and Kalb, ibid., 22.
2
G. Grund, Zeitschr. f. Biol., 54.
J
See also Svenson, Zeitschr. f. klin. Med., 43.
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