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al
nation power set back, growth would take place when the spores
were brought into favorable conditions for development.
The action of the gastric and other juices in the digestive appa-
ratus may be considered next. The antiseptic properties of gastric
juice due to the presence of free hydrochloric acid have long been
recognized. The earlier investigators of the intestinal flora e. g.
BIENSTOcH attributed to the gastric juice an extraordinary power of
killing foreign microorganisms (KÜSTER 34). Recent researches,
especially those of KOHLBRUGGE (32), have shown, however, that
any generalization on this point is not possible. Different micro-
organisms show different degrees of resistance, and although the
stomach has no specialized bacterial flora, »wilde Keime» are con-
stantly found in the ingesta and reach the intestine in spite of the
gastric juice. This may partly be explained by the inability of the
gastric juice to penetrate the ingesta (KOHLBRUGGE 32). Asa result
of this only the outermost layers of the food are acted upon, while
the inner parts show neutral or alkaline reaction (MACFAYDEN,
NENCKI, and SIEBER 40). While it is easy to conceive of micro-
organisms escaping the acidsecreting mucosa of animals, particularly
in herbivorous animals, in this way, it becomes doubtful whether
in man a similar escape is possible. The fate of a given organism
that has reached the stomach of man, is probably determined
exclusively by its ability to resist the unfavorable conditions which
it is being exposed to there.
To test the action on fungous spores of a concentration of hyd-
rochloric acid identical with that present in the stomach, artificial
gastric juice of the following formula was prepared (HALLIBURTON 21):
Water 9934 100 CaCls 77 One® Cal * (PO),
x Pepsin 05:0 UNSCI 2003229 MSS (PO); 0.0
HCl 0... KCl 0:5 t FePO; |
The liquid was distributed in test tubes, inoculated with different
moulds and kept at room temperature. Germination and growth
occurred in Penicillium notatum and P. frequentans as well as in the
thermophilous species isolated from warm-blooded animals.
These results seem to be in accordance with those of FERMI (15)
who grew successfully »P.:glaucum» and many thermophilous spe-
cies of Aspergillus in acid pepsin of the following composition:
pepsin 1,5 g; hydrochloric acid 1 g.; glycerine 1 g.; aqua dist. 500 c. c.
With regard to the effect of other digestive juices experiments
have shown that the bile and pancreatic juice do not possess any
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