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17
In no case was mycosis induced by the injections. The results
obtained corroborate the fact that high optimum temperature of a
mould is no indication of its pathogenity.
Sopp (60) has recently called attention to certain species of
Penicillium e. g. P. virescens, which thrives at body-temperature and
which therefore is by him suspected to cause mycosis. He even
endeavors to explain Grawitz’s acclimatization experiments with
> Penicillium glaucum» and its supposed pathogenity, so emphatically
propounded by this author {Grawitz (8), on the basis of impurity
of the cultures used, due to contamination by some such form as
Penicillium virescens. It is doubtful whether such a view is warranted
befere any injection experiments have been made with spores of
these thermophilous penicillia.
The injections made and recorded in the above, show that not
only Penicillium divaricatum with an optimum of 37° C. is without
mycotic effects, but also ‘Aspergillus terreus and A. umbrinus both
having their optima at about 37° C. However, this shall not be
taken to mean that moulds are without any toxic effect as long as
they do not vegetate within the body. On the contrary, it will be
shown in the following that the toxicity of moulds to man and
other animals does not necessarily depend on intrabodily growth.
8. Feeding Experiments on Rabbits with Moulds from
Human and Animal Faeces.
Microscopic examinations of human faeces undertaken with the
hope of finding mycelium gave invariably negative results. Even
samples with a high percentage of fungous spores were found to
be absolutely free from mycelium. It seems therefore reasonably
certain, that germination and growth of pathogenic moulds does
not take place in the digestive tract of healthy persons. The
statement of CENI (see OTTO 46) that spores of Aspergillus fumigatus
and A. flavus are able to penetrate the intestinal wall, thereby
gaining access to organs more suitable for the growth of these
fungi, evidently refers to already diseased individuals. Through
the works of Opirz (45) and Scuorr (56) it is fairly well established
that bacteria are unable to migrate through the intestinal wall, and
there is no positive evidence for the belief that moulds are able to
accomplish such penetration.
Svensk Botanisk Tidskrift 1916. 2
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