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16
Especially have LINDT (39) and LicurHEIM (37, 38) made valuable
contributions to this subject.
Mycosis of the digestive apparatus has been reported several
times. MOHLER and BuckLEy (42) quote FRANK (1890) and Lucer
(1897) both having found intestinal aspergillosis in animals. They
also refer to CENI, who records a number of instances in man.
EINHORN (13) reports four cases of gastric mycosis in persons
suffering with hyperchlorhydria and figures the fungus, which in
‘all probability is an Oidium. Also Orro (46) mentions a case of
mycosis intestinalis and gives references to a number of other cases
reported in the medical literature. Both Orro (46) and RENON (52)
succeeded in producing the disease experimentally by feeding
animals with spores of Aspergillus fumigatus.
7. Intravenous Injections in Rabbits of certain
Intestinal Moulds.
As at least three of the fungi found in the alimentary canal of
man, namely Aspergillus terreus, A. umbrinus, and Penicillium
divaricatum have never before been reported as occurring within
the human body, and furthermore, as considerable theoretical in-
terest is connected with the question of the pathogenity or non-
pathogenity of these species, injections were made intravenously in
rabbits, of spores of these moulds. The results of the injections
are given below.
RABBIT I. 0.25 c. c. of spores of Penicillium divaricatum were
injected in the middle ear vein. No mycotic symptoms were seen
at the end of two weeks.
RABBIT II. 0.5 c. c. of spores of P. divaricatum were injected in
the same vein. The animal remained alive. When killed and
examined at the end of two weeks, the kidneys, lungs, and the
liver were found to be perfectly normal.
RABBIT III. 0.5 c. c. of spores of Aspergillus terreus were injected
through the middle ear vein. The animal remained perfectly
healthy.
RABBIT tv. 0.5 c. c. of spores of Aspergillus umbrinus were injected
through the same vein. Any mycotic symptoms could not be
noticed at the end of two weeks.
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