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SUGAR IN THE BLOOD. 329
of the blood, plasma and blood-corpuscles may be ascertained. In the
table on page 328 are given analyses of the blood of various animals by
Abderhalden 1
according to Hoppe-Seyler’s and Bunge’s methods.
The analyses of human blood by C. Schmidt 2
are older and were made
according to another method, hence the results for the weights of the
corpuscles are perhaps a little too high. All the results are in parts per
1000 parts of blood.
The relation between blood-corpuscles and plasma may vary con-
siderably under different circumstances even in the same species of animal.
In animals, in most cases considerably more plasma is found, some-
times two-thirds of the weight of the blood.3
For human blood Arronet
has found 478.8 p. m. blood-corpuscles and 521.2 p.m. serum (in defibrinated
blood) as an average of nine determinations. Schneider 4
found 349.6
and 650.4 p. m. respectively in women.
The sugar was considered as occurring only in the serum and not with
the blood-corpuscles. According to the investigations of Rona and
Michaelis the blood-corpuscles of the dog contain considerable amounts
of sugar; and the quantity of sugar in the blood, in the blood-corpuscles
as well as in the plasma, is increased in man with diabetes mellitus.
Hollinger 5
also found that in man, with normal quantity of sugar
in the blood, the sugar was distributed almost equally between the
blood-corpuscles and the plasma.
The amount of sugar in the blood-corpuscles, which was shown by
Lepixe and Boulud before Michaelis and Rona, has been the sub-
ject of numerous investigations by Bang and his pupils, Lyttkens and
Sandgren on the one hand and by Rona, Michaelis, Takahashi,
Frank and others on the other hand 6 . The results of these investiga-
tions are so contradictory that it is hardly possible for the present to
draw any positive conclusions. It seems to follow from them, nevertheless,
that the dog blood-corpuscles always contain sugar, while for the corpuscles
of the rabbit and man the conditions are somewhat doubtful and may
be variable (Frank and Bretschneider). According to Lyttkens
and Sandgren the blood-corpuscles of man contain as maximum 0.06
1
Zeitschr. f. physiol. Chem., 23 and 85.
1
Cited and in part recalculated from v. Gorup-Besanez, Lehrb. d. physiol Chem.,
4. Aufl., 345.
’See Sacharjin in Hoppe-Seyler’s Physiol. Chem., 447; Otto, Pfliiger’s Arch.,
35; Bunge. Zeitschr. f. Biol., 12; L. and M. Bleibtreu, Pfliiger’s Arch., 51.
4
Arronet, Maly’s Jahresber., 17; Schneider, Centralbl, f. Physiol.. 5, 362.
5
Rona and Michaelis, Bioch. Zeitschr. 16 and 18; Hollinger, ibid.. 17.
6
Lupine and Boulud, Bioch. Zeitschr., 32; Lyttkens and Sandgren, ibid., 26, 31.
36: Rona with Doblin, ibid., 31, with Michaelis, ibid., 37, with Takahashi, ibid., 30;
Takahashi, ibid., 37; E. Frank, Zeitschr. f. physiol. Chem., 70, with Bretschneider,
ibid., 71 and 76; see also Oppler, ibid., 64 and 75.
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