Full resolution (JPEG) - On this page / på denna sida - VI. Chyle, Lymph, Transudates and Exudates - II. Transudates and Exudates
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
354 CHYLE, LYMPH, TRANSUDATES AND EXUDATES.
perhaps in the cerebrospinal fluid, and in those cases where an autolysis
has taken place in the liquid. 1
The non-inflammatory transudates do
not as a rule undergo spontaneous coagulation or do so only very slow-
ly. On the addition of blood or blood-serum they coagulate. Inflam-
matory exudates coagulate spontaneously, and Paijkull has shown
that these often contain nucleoprotein (or nucleoalbumin) . In inflam-
matory exudates a protein substance has been habitually observed which
is precipitated by acetic acid, but which does not occur in transudates,
or only in very small quantities. This substance, which has been observed
and studied by Moritz, Staehelin, Umber, and Rivalta, is claimed
by the first three observers to be free from phosphorus, while Rivalta
considers it to be a phosphorized pseudoglobulin. Umber calls it sero-
samucin, although it yields only very little reducing carbohydrate.
According to Joachim 2
it is only a part of the globulin, a view which can-
not be correct for all cases, v. Holst 3 has so far substantiated Umber’s
observation in that he has isolated a mucin substance from an ascitic
fluid in carcinoma of the stomach and the peritoneum, which seemed to
be identical with Umber’s serosamucin, as well as with the synovial
mucin. There does not seem to be any doubt that in transudates and
exudates, different protein substances may occur under different cir-
cumstances, although the globulins form besides seralbumin the principal
mass of the protein bodies. Mucoid substances, which were first
observed by Hammarsten in certain cases of ascites without complica-
tions with ovarial tumors, and which are cleavage products of a more
complicated substance, seem according to Paijkull 4
to be regular
constituents of transudates and are closely related to the above-men-
tioned serosamucin. The occurrence of the above-mentioned substances
precipitable by acetic acid, the globulins (Rivalta) and the nucleo-
proteins, in puncture fluids, has been recognized as of very great impor-
tance in the differential diagnosis between transudates and exudates.
There are numerous investigations on the relation between glob-
ulin and seralbumin, and Joachim has determined the relation between
euglobulin and the total globulin. No conclusive results can be drawn
from these determinations. The relation between globulin and seral-
bumin varies very much in different cases, but, as Hoffmann and
1
Umber, Munch, med. Wochenschr., 1902, and Berlin, klin. Wochenschr., 1903.
In regard to the autolysis in transudates, see also Galdi, Biochem. Centralbl., 3;
Eppinger, Zeitsehr. f. Heilkunde, 25, and Zak, Wien. klin. Wochenschr., 1905.
-
Paijkull, 1. c; Moritz, Munch, med. Wochenschr., 1903; Staehelin, ibid., 1902,
Qmber, Zeitsehr. f. klin. Med., 48; Rivalta, Biochem. Centralbl., 2 and 5; Joachim;
Pfltlger’e Arch., 93.
3
Zeitsehr. f. physiol. Chem., 43.
4
Hammarsten, ibid., 15; Paijkull, 1. c.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
