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579

(1914) [MARC] Author: Olof Hammarsten Translator: John Alfred Mandel With: Gustaf Hedin - Tema: Chemistry
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INOSITE. 579
In the analysis of moat, and for the detection and separation of the various
extractive bodies of meat, we make use of the systematic method as suggested
by Gautier, 1
for details of which the reader is referred to the original article
Bfl well as for the Kutscht r method for working the meat extracts.
The non-nitrogenous extractive bodies of the muscles are inosite, gly-
cogen, sugar, and lactic aval.
Inosite, CgHi20c+H20 = C6Hg(OH)6+H20. This body, discovered
by Scherer, is not a carbohydrate, but belongs to the hydroaromatic
compounds, and is a hexahydroxybenzene (Maquenne 2
). That it
stands in certain relation to the carbohydrates follows from the fact that
Neuberg obtained some furfurol from inosite by distillation with phos-
phoric anhydride, and also that P. Meyer 3
found fermentation lactic
acid in the urine of rabbits after the introduction of inosite per os. It
has been known for some time that inosite undergoes lactic acid fermenta-
tion. The acid formed thereby is sarcolactic acid according to Hilger
and fermentation lactic acid according to Vohl.4
Inosite is found in the muscles, liver, spleen, leucocytes, kidneys,
suprarenal capsule, lungs, brain, testicles, and in the urine in pathological
cases, and as traces in normal urine. It is found very widely dis-
tributed in the vegetable kingdom, especially in the unripe fruit of green
beans (Phaseolus vulgaris), and therefore it is also called phaseomannite.
In the plant kingdom another substance occurs which is called phytin
and which is the Mg and Ca compound of inosite and phosphoric acid
and which was first isolated by Posternak. Winterstein identified this
as an inosite-phosphoric acid. This inosite-phosphoric acid can be split
into phosphoric acid and inosite by the plant enzyme phytase (Suzuki,
Yoshimura and Takaishi) as well as by enzymes of the animal tissues
(Starkenstein). Inosite is found in plants, especially in the develop-
ing organs (Meillere), and according to Starkenstein 5
it occurs to a
greater extent in the organs of young animals as compared with those of
older animals. From this it follows that inosite is probably not a decom-
position product of metabolism, but rather a body necessary for the devel-
opment of the cells (Meillere); but according to Starkenstein the
facts are different.
1
Maly’s Jahresb., 22.
2
Bull. soc. chem. (2), 47 and 48; Compt. Rend., 104.
1
Neuberg, Bioch. Zeitschr., 9; P. Meyer, ibid., 9.
* Hilger, Annal. d. Chem. u. Pharm., 160; Vohl, Ber. d. d. Chem. Gesellsch., 9.
5
Winterstein, Ber. d. d. chem. Gesellsch., 30; :>.nd Zeitschr. f. physiol. chem., 58;
Posternak, Contribution a l’dtude chim. de I’assimilation chlorophyllienne. Revue
cenerale botanique, Tome 12 (1900), and Compt. Rend., 137; Suzuki, Yoshimura and
Takaishi, Bull, agric. Univers. Tokio, 7; Starkenstein, Bioch. Zeitschr., 30.

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