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INDOXYL-SULPHURIC ACID. 729
The putrefaction of proteins in other organs and tissues besides the
intestine may also cause an increase in the indican of the urine. Cer-
tain investigators, Blumenthal, Rosenfeld, and Lewin, claim to
have shown that an increased excretion of indican can also be brought
about without putrefaction by an increased destruction of tissue in starva-
tion and also after phlorhizin poisoning; but these statements are vehe-
mently opposed by other investigators, such as P. Mayer, Scholz, and
Ellinger, and are improbable. The indol, it seems, is not formed from
the tryptophane (indolaminopropionic acid) as intermediary step in the
demolition of the proteins in the animal body, but rather from the
putrefaction of the tryptophane in the intestine. Gentzen * has also
shown that tryptophane introduced subcutaneously or per os into the
body does not lead to an indicanuria, but only when it is exposed to bac-
terial decomposition in the large intestine. The reports as to the elimina-
tion of indican after oxalic-acid poisoning are conflicting. After poison-
ing with oxalic acid Harnack and v. Leyen found an increased indican
elimination, and Moraczewski believes he has proven a certain par-
allelism between the quantity of indican and the quantity of oxalic acid
in diabetes. Scholz,2
on the contrary, obtained no increase in the
excretion of indican after oxalic-acid poisoning.
The excretion of indican is, as above stated, increased by the introduction of
indol, but also by indoxyl or indoxyl-c£rboxylic acid. Indol-carboxylic acid,
on the contrary, does not yield indican, but, according to Porcher and Her-
vieux, another ehromogen. Benedicenti has also shown that indigo blue or
analogous blue or green pigments are produced only from those derivatives
CH CH
of indol which, like n-methyl indol C6 H4
\ /CH, a-naphtindol, GoH6\ /CH or
N.CH, NH
CH,
n-methylindolin, C6H4
\’ y>CH2 ,do not have the hydrogen atoms of the two methine
X.CH3
groups substituted by alkyl. From those derivatives in which one or two hydro-
gen atoms are substituted by alkyl, such as skatol, a-methyl indol, dimethyl indol,
C.CH3 CH
C6 H4 <J^C.CH3 ,
and bz. 3, p. 2-dimethyl indol, CH3 .GH3<^\c.CH3, red pig-
NH XH
1
Blumenthal, Arch. f. (Anat. u.) Physiol., 1901, Suppl, and 1902, with Rosenfeld,
Charite annalen, 27, and Hofmeister’s Beitrage, 5; Lewin, Hofmeister’s Beitrage, 1;
Mayer, Arch. f. (Anat. u.) Physiol., 1902, Zeitschr. f. klin. Med., 47, and Zeitschr. f.
physiol. Chem., 29, 32; Scholz, ibid., 38; Ellinger, ibid., 39; Gentzen, " Ueber die Vor-
stufen des Indols bei der Eiweissfaulnis im Thierkorper," Inaug.-Dissert.. Konigsberg,
1904.
2
Harnack, Zeitschr. f. physiol. Chemie, 29; Scholz, 1. c, Moraczewski, CentralbL
f. innere Med., 1903.
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